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Estrogen-mediated post transcriptional down-regulation of P-glycoprotein in MDR1-transduced human breast cancer cells

✍ Scribed by Kazuyoshi Mutoh; Satomi Tsukahara; Junko Mitsuhashi; Kazuhiro Katayama; Yoshikazu Sugimoto

Book ID
108583737
Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
282 KB
Volume
97
Category
Article
ISSN
1347-9032

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Estrogen regulated expression of the p21
Estrogen regulated expression of the p21Waf1/Cip1 gene in estrogen receptor positive human breast cancer cells
✍ Soma Mandal; James R. Davie πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons 🌐 English βš– 183 KB

## Abstract The cyclin‐dependent kinase inhibitor protein p21^Waf1/Cip1^ is a potent tumor suppressor. Here, we demonstrate that estradiol regulates the p21^Waf1/Cip1^ gene. Estradiol induces p21^Waf1/Cip1^ mRNA expression within 30–60 min independent of new protein synthesis in the estrogen recept