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Radiotherapy as a cisplatin-sensitizer in a resistant ovarian carcinoma cell line

✍ Scribed by David F. Silver; Clifford R. Wheeless Jr.; Norman H. Dubin

Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
326 KB
Volume
77
Category
Article
ISSN
0008-543X

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✦ Synopsis

BACKGROUND.

Stage 111 ovarian carcinoma has shown resistance to adjuvant chemotherapy following surgical cytoreduction. With recurrence of ovarian carcinoma, cell lines may develop resistance to previously used chemotherapy. This contributes to the fact that survival rates for patients with ovarian carcinoma have not been dramatically improved in decades. The objective of this study is to evaluate radiotherapy as a cisplatin-sensitizer in a cisplatin-resistant ovarian carcinoma cell line.

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✍ Sylvie Maubant; SΓ©verine Cruet-Hennequart; Laurent Poulain; Franck Carreiras; Fr πŸ“‚ Article πŸ“… 2001 πŸ› John Wiley and Sons 🌐 French βš– 416 KB

## Abstract In order to elucidate the mechanisms underlying the development of chemoresistance in ovarian cancer, we have previously established the IGROV1‐R10 cisplatin‐resistant cell line by mimicking a clinical protocol of drug administration on IGROV1 human ovarian carcinoma cells. Both IGROV1