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Radiosynthesis of tritium-labeled novel nitromethylene neonicotinoids compounds with NaB3H4

✍ Scribed by Chao Li; Xiao-Yong Xu; Ju-Ying Li; Qing-Fu Ye; Zhong Li

Publisher
John Wiley and Sons
Year
2011
Tongue
French
Weight
111 KB
Volume
54
Category
Article
ISSN
0022-2135

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✦ Synopsis

Paichongding and Cycloxaprid are two novel neonicotinoids with good industrialization prospects for their high activity against imidacloprid-resistant pest. In this paper, the radiosynthesis of [ 3 H 2 ]-Paichongding and [ 3 H 2 ]-Cycloxaprid was achieved using a NaB 3 H 4 reduction. The title compounds were obtained with chemical purities of 98.7 and 98.4%, and radiochemical purities of 97.3 and 98.6%, respectively. The labeled compounds could be used as radiotracers for further study of metabolism and toxicology.

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