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Radiosynthesis of the D2/3 agonist [3-11C]-(+)-PHNO using [11C]iodomethane

✍ Scribed by Francisco Garcia-Arguello, Segundo; Fortt, Robin; Steel, Colin J.; Brickute, Diana; Glaser, Matthias; Turton, David R.; Robins, Edward G.; Årstad, Erik; Luthra, Sajinder K.

Book ID
122049796
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
447 KB
Volume
73
Category
Article
ISSN
0969-8043

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Brain region binding of the D2/3 agonist [11C]-(+)-PHNO and the D2/3 antagonist [11C]raclopride in healthy humans
✍ Ariel Graff-Guerrero; Matthaeus Willeit; Nathalie Ginovart; David Mamo; Romina M 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 412 KB

## Abstract The D~2~ receptors exist in either the high‐ or low‐affinity state with respect to agonists, and while agonists bind preferentially to the high‐affinity state, antagonists do not distinguish between the two states. [^11^C]‐(+)‐PHNO is a PET D~2~ __agonist__ radioligand and therefore pro