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Effects of d-amphetamine on binding of the new D2/3 receptor agonist radioligand [11C]-(+)-PHNO in humans

✍ Scribed by Matthaeus Willeit; N. Ginovart; A. Graff; P. Rusjan; P. Bloomfield; I. Vitcu; S. Houle; A.A. Wilson; S. Kapur

Book ID
118489945
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
57 KB
Volume
31
Category
Article
ISSN
1053-8119

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## Abstract The D~2~ receptors exist in either the high‐ or low‐affinity state with respect to agonists, and while agonists bind preferentially to the high‐affinity state, antagonists do not distinguish between the two states. [^11^C]‐(+)‐PHNO is a PET D~2~ __agonist__ radioligand and therefore pro