Radiosynthesis of (Tetrazoyl-11C)irbesartan, a Non-Peptidic Angiotensin II Antagonist. -A one-pot procedure for labeling the tetrazole moiety is developed. The resulting irbesartan (V) is not suitable for studying myocardial angiotensin II receptor with positron-emission tomography. -(
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Radiosynthesis of [tetrazoyl-11C]irbesartan, a non-peptidic angiotensin II antagonist
โ Scribed by M Ponchant; S Demphel; F Hinnen; C Crouzel
- Book ID
- 108422153
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- French
- Weight
- 631 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0223-5234
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DuP 532, 2-propy1-4-pentafluoroethyl-l-[ [2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methylJ imidazole-5-carboxylic acid, is an orally active, non-peptide angiotensin I1 (AII) receptor antagonist. DuP 532 is more potent and longer acting than losartan, another A11 receptor antagonist currently undergoing ph