We studied the effects of the spermine analogue N',N14-bis-(ethyl)-homospermine (BE-4-4-4) on growth, survival and polyamine levels in cultured U-251 MG and SF-188 human brain tumor cells. After 48 hr of treatment at concentrations of I )LM or higher, BE-4-4-4 accumulated in cells with a concomitant
โฆ LIBER โฆ
Radiopotentiation of human brain tumor cells by the spermine analog N1, N14-bis(ethyl)homospermine
โ Scribed by Chun-Zhang Chen; Lily J. Hu; Raymond J. Bergeron; Laurence J. Marton; Dennis F. Deen
- Book ID
- 103727791
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- English
- Weight
- 765 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0360-3016
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The polyamine analogue N 1 ,N 12 bis(ethyl)spermine (BESpm) is a potent inhibitor of cell proliferation and is representative of a class of agents currently in clinical trials. Previous studies have demonstrated that BESpm treatment can produce a decrease in the mRNA levels of the protooncogene c-my