Mechanism of the inhibition of cell growth by N1, N12-bis(ethyl)spermine
โ Scribed by Jun-ichi FUKUCHI; Keiko KASHIWAGI; Kuniko KUSAMA-EGUCHI; Kiyoshi TERAO; Akira SHIRAHATA; Kazuei IGARASHI
- Book ID
- 115129641
- Publisher
- John Wiley and Sons
- Year
- 1992
- Tongue
- English
- Weight
- 763 KB
- Volume
- 209
- Category
- Article
- ISSN
- 1432-1327
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The polyamine analogue N 1 ,N 12 bis(ethyl)spermine (BESpm) is a potent inhibitor of cell proliferation and is representative of a class of agents currently in clinical trials. Previous studies have demonstrated that BESpm treatment can produce a decrease in the mRNA levels of the protooncogene c-my
The results presented here demonstrate that a cisdiamminedichloroplatinum(II) (DDP)-resistant human ovarian-carcinoma cell line is also cross-resistant to the spermine analogue N 1 ,N 12 -bis(ethyl)spermine (BESPM). We report that C13\* cells, which are approximately 20-fold resistant to DDP, simila