𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Radioiodination of iodinated estradiol-17-diphosphates

✍ Scribed by M. Tarle; R. Padovan; Š. Spaventi

Book ID
102900892
Publisher
John Wiley and Sons
Year
1978
Tongue
French
Weight
597 KB
Volume
15
Category
Article
ISSN
0022-2135

No coin nor oath required. For personal study only.

✦ Synopsis

exchange labeling Estradiol and its mono and diiodo derivatives were converted to their 17-diphosphate analogs. Radioiodine labeling of monoiodinated eetradiol diphosphates with 1251 proceeds smoothly in cuprous chloride catalyzed exchange reaction utilizing acetonitrile-ethanol (1:l) as a solvent. Structural aseignmente of unlabeled compounds were made by means of mass spectral data,elemental analysis,and qualikative tests. Radiochromatographic analysis furnished information on the identity of radioiodinated products. Labeling yields up to 35-40% were achieved. Two possible mechanistic interpretations of cuprous ion catalyzed exchange labeling are proposed and their relative merits discussed. The results described in this paper seem to prefer,in harmony with argroraents put forward in some previous studies,the exchange labeling vening SNRl type reaction. a four center transition state over an inter-

📜 SIMILAR VOLUMES

Electrochemical radioiodination of estra
Electrochemical radioiodination of estradiol
✍ David H. Moore; Walter Wolf 📂 Article 📅 1978 🏛 John Wiley and Sons 🌐 French ⚖ 293 KB

An electrochemical iodination procedure was used t o synthesize 2-iodoestradi 01 -1251 and 4-fodoestradiol -l Z 5 I . These agents were prepared i n order t o be studied as potential tunorl o c a l i z i n g radiophannaceuticals t h a t might d i f f e r e n t i a t e estrogen-responsive from non-re

A-ring iodination of estradiol
A-ring iodination of estradiol
✍ Sweet, Frederick; Patrick, Timothy B.; Mudd, Jackquline M. 📂 Article 📅 1979 🏛 American Chemical Society 🌐 English ⚖ 460 KB