Electrochemical radioiodination of estradiol

✍ Scribed by David H. Moore; Walter Wolf

• Book ID: 102371694
• Publisher: John Wiley and Sons
• Year: 1978
• Tongue: French
• Weight: 293 KB
• Volume: 15
• Category: Article
• ISSN: 0022-2135
• DOI: 10.1002/jlcr.2580150150

✦ Synopsis

An electrochemical iodination procedure was used t o synthesize 2-iodoestradi 01 -1251 and 4-fodoestradiol -l Z 5 I . These agents were prepared i n order t o be studied as potential tunorl o c a l i z i n g radiophannaceuticals t h a t might d i f f e r e n t i a t e estrogen-responsive from non-responsive breast tumors. The advantages o f the electrochemical iodination procedures, as opposed t o other chemical and enzymatic methods o f iodination, are the higher percentage o f incorporation o f iodine, shorter reaction time, selective monoiodination, and a very l i m i t e d amount o f impurities as by-products o f the reaction.