Radioiodinated monoclonal antibodies
β Scribed by S.J. Mather
- Publisher
- Elsevier Science
- Year
- 1988
- Tongue
- English
- Weight
- 952 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0020-711X
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A new radioiodination reagent, 3-iodophenylisothiocyanate (3-IPI) has been developed for coupling to monoclonal antibodies. The starting material, 3-tri-n-butylstannylphenylisothiocyanate was prepared via a reaction of hexabutylditin with 3-bromoaniline, followed by treatment with thiophosgene with
## Abstract Ten arylβcarbohydrate ligands have been synthesized that potentially increase the tumor retention and decrease the deiodination of iodinated monoclonal antibodies used in the imaging and treatment of cancer. The compounds were synthesized via reductive amination reactions, purified with