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Synthesis and radioiodination of ten aryl-carbohydrate compounds for labeling monoclonal antibodies

✍ Scribed by S. D. Warren; S. A. Ali; K. Y. Richter; K. A. Krohn

Publisher
John Wiley and Sons
Year
1990
Tongue
French
Weight
592 KB
Volume
28
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

Ten aryl‐carbohydrate ligands have been synthesized that potentially increase the tumor retention and decrease the deiodination of iodinated monoclonal antibodies used in the imaging and treatment of cancer. The compounds were synthesized via reductive amination reactions, purified with cation exchange chromatography, and characterized using ^1^H and ^13^C NMR. These compounds were then radioiodinated to assess their iodination characteristics, for subsequent experiments involving attachment to monoclonal antibodies.

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