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Radioactively labelled epoxides part II. (1) tritium labelled cyclohexene oxide, transstilbene oxide and phenanthrene 9,10-oxide

✍ Scribed by Franz Oesch; Alan J. Sparrow; Karl L. Platt

Publisher
John Wiley and Sons
Year
1980
Tongue
French
Weight
344 KB
Volume
17
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

Tritium labelled cyclohexene oxide, trans‐stilbene oxide and phenanthrene 9,10‐oxide were prepared with specific activities of 0.7 ‐ 1.1 mCi per mmole starting with monoor diketo compounds.

Tritium was introduced by reducing the ketone precursors with tritiated complex metal hydrides.

The resulting alcohols were transformed to the epoxides by methods described for the unlabelled compounds.

The syntheses require only two or three steps and yield cyclohexene oxide, trans‐stilbene oxide and phenanthrene 9,10‐oxide, important substrates for the study of epoxide hydratase and glutathione S‐transferases in high radiochemical purity.

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