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Radioactively labelled epoxides. Part VI. tritium-labelled mono- and dimethyl substituted phenyl oxiranes (styrene oxides)

✍ Scribed by Frans Setiabudi; Franz Oesch; Karl L. Platt

Publisher
John Wiley and Sons
Year
1988
Tongue
French
Weight
342 KB
Volume
25
Category
Article
ISSN
0022-2135

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✦ Synopsis

Tritium-labelled (E)and (1)-2,3-dimethyl-Z-phenyl oxirane Q, (E)and (Z)-Z-methyl-3-phenyl o x i rane I and 2.2-dimethyl -3-phenyl o x i Pane 11 have been prepared by reduction o f t h e corresponding bromoketones w i t h sodium b o r o t r i t i d e t o the corresponding bromohydrins followed by c y c l i z a t i o n t o the oxiranes. These oxiranes were successfully used as diagnostic subs t r a t e s t o d i s t i n g u i s h between d i f f e r e n t forms o f epoxide hydrolase and glutathione transferase.

📜 SIMILAR VOLUMES

Radioactively labelled epoxides. Part IV
Radioactively labelled epoxides. Part IV. Tritium labelled α- and β-methyl styrene oxides
✍ Franz Oesch; Alan J. Sparrow; Karl L. Platt 📂 Article 📅 1983 🏛 John Wiley and Sons 🌐 French ⚖ 269 KB

The two geometrical isomers o f B-methyl s t y r e n e oxide were synthesized by a sequence o f r e a c t i o n s which l e d t o stereochemic a l l y pure products, and o b v i a t e d any need t o separate t h e isomers.