Radioactive synthesis and biodistribution study of β-elemene–99mTc(CO)3conjugates
✍ Scribed by Yanhong Sun; Yunfeng Ren; Hua Zhu; Yuanqing Zhang; Guifeng Liu; Chunchun Zhang; Liliang Huang; Jia Xu; Yujin Qi; Yu-Mei Shen
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 387 KB
- Volume
- 14
- Category
- Article
- ISSN
- 1432-1327
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## Abstract ^99m^Tc‐CO‐MIBI was prepared by a two‐step procedure involving the convenient preparation of the [^99m^Tc(CO)~3~(OH~2~)~3~]^+^ precursor and followed by the substitution of the water molecules by the MIBI (2‐methoxyisobutylisonitrile) ligands. In a second step, the reaction solution was
The organometallic precursor fac-[ 99m Tc(OH 2 ) 3 (CO) 3 ] + was reacted with trimethyl-bromoacetanilido-iminodiacetic acid (mebrofenin) in phosphate buffered saline (pH 7) at 708C for 1 h to produce the complex, 99m Tc(CO) 3mebrofenin, in >95% yields. High performance liquid chromatography analysi