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Radical-mediated stereoselective synthesis of (+)-dihydrocanadensolide and (−)-3-epi-dihydrocanadensolide from d-xylose

✍ Scribed by G.V.M Sharma; T Gopinath

Publisher
Elsevier Science
Year
2001
Tongue
French
Weight
98 KB
Volume
42
Category
Article
ISSN
0040-4039

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✦ Synopsis

An intramolecular radical cyclisation protocol on 5-hexenyl systems was utilised for the first time in a synthesis of (+)-dihydrocanadensolide and its C-3 epimer. This study also revealed the effect of the additional stereocentre at the 2%-position of the radical systems.

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Radical cyclisation approach for the syn
Radical cyclisation approach for the synthesis of (+)dihydrocanadensolide, (+)dihydrosporothriolide and their C-3 epimers from d-xylose
✍ G.V.M Sharma; T Gopinath 📂 Article 📅 2003 🏛 Elsevier Science 🌐 French ⚖ 295 KB

Intramolecular radical cyclisation protocol on 5-hexenyl systems derived from D-xylose, was utilized for the synthesis of (þ)dihydrocanadensolide, (þ)-dihydrosporothriolide and their C-3 epimers, wherein a study on the impact of C-2 0 stereocentre on radical cyclisation was conducted.