Radical deoxygenation and dehalogenation of nucleoside derivatives with hypophosphorous acid and dialkyl phosphites

✍ Scribed by Satoshi Takamatsu; Satoshi Katayama; Naoko Hirose; Masaki Naito; Kunisuke Izawa

• Book ID: 104231665
• Publisher: Elsevier Science
• Year: 2001
• Tongue: French
• Weight: 69 KB
• Volume: 42
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(01)01617-3

✦ Synopsis

Hypophosphorous acid and dialkyl phosphites are effective radical reducing agents for O-thiocarbonyl groups or halides at the sugar part of nucleoside derivatives and give the corresponding hydrocarbons in high yield.