Radiation-induced point mutations, deletions and micronuclei in lacI transgenic mice
โ Scribed by Richard A. Winegar; Louise H. Lutze; Janice D. Hamer; Kathleen G. O'Loughlin; Jon C. Mirsalis
- Book ID
- 113194673
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- English
- Weight
- 682 KB
- Volume
- 307
- Category
- Article
- ISSN
- 0027-5107
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The advent of transgenic technology has greatly fa-deamination-directed mutation at methylated cytocilitated the study of mutation in animals in vivo. sine bases. The second most common class of muta-The Big Blue mouse system, transgenic for the lacI tions is G:C r T:A transversions. A significant c
The induction and nature of mutations in the lacI transgene were evaluated in multiple tissues after exposure of adult male B6C3F1 lacI transgenic mice to cyclophosphamide (CP). Mice were given a single i.p. injection of 25 mg CP/kg, 100 mg CP/kg, or vehicle (PBS) and then necropsied 6 weeks after t