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Radiation-induced genetic instability in vivo depends on p53 status

✍ Scribed by Li Liang; Changshun Shao; Li Deng; Marc S. Mendonca; Peter J. Stambrook; Jay A. Tischfield

Book ID
114070584
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
170 KB
Volume
502
Category
Article
ISSN
0027-5107

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In mouse mammary tumorigenesis, p53 mutations facilitate tumorigenesis in concert with other oncogenic alterations. Ionizing radiation enhances tumorigenesis in preneoplastic mammary outgrowth lines and induces p53-dependent apoptosis. We asked if normal p53 function modulates radiation-induced tumo