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Chromosome instability in human hepatocellular carcinoma depends on p53 status and aflatoxin exposure

✍ Scribed by Pascal Pineau; Agnès Marchio; Carlo Battiston; Emilie Cordina; Alessandro Russo; Benoît Terris; Lun-Xiu Qin; Bruno Turlin; Zhao-You Tang; Vincenzo Mazzaferro; Anne Dejean

Book ID
116759422
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
504 KB
Volume
653
Category
Article
ISSN
1383-5718

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Characterization of a murine p53SER246 m
Characterization of a murine p53SER246 mutant equivalent to the human p53SER249 associated with hepatocellular carcinoma and aflatoxin exposure
✍ Nader Ghebranious; Brian J. Knoll; Hongyun Wu; Guillermina Lozano; Stewart Sell 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 English ⚖ 736 KB

## Abstract A mutation in the tumor suppressor __p53__ gene resulting in an Arg→Ser substitution in position 249 is found frequently in human hepatocellular carcinomas associated with hepatitis B infection and with aflatoxin exposure. To determine the significance of this mutation in an in vivo exp