Radiation-Induced Chromosome 2 Rearrangement and Initiation of Murine Acute Myeloid Leukemia
โ Scribed by A. R. J. Silver, G. Breckon, W. K. Masson, J. Adam, J. Boultwood and R. Cox
- Book ID
- 124692265
- Publisher
- Bioone
- Year
- 1990
- Tongue
- English
- Weight
- 132 KB
- Volume
- 121
- Category
- Article
- ISSN
- 0033-7587
- DOI
- 10.2307/3577770
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Cytogenetic and molecular studies have provided evidence of the clustering of chromosome 2 deletion breakpoints in radiation-induced murine acute myeloid leukemia (AML). Moreover, clustering occurs in at least two fragile domains rich in telomere-like arrays. Here we describe a physical map of the d
Acute myeloid leukaemias (AML) arising in irradiated CBA/H mice frequently have breakpoints in the F region of chromosome 2. The closely linked cytokine genes interleukin (/L)-/a and p map to this region, and the p gene is deregulated in some AMLs. Using pulsed-field gel electrophoresis techniques,