Male breast cancer (MBC) is a rare disease and, because of its rarity, its etiology is poorly understood. However, germ-line mutations in breast cancer susceptibility gene BRCA2 are known to predispose to MBC. 1 Male carriers of BRCA2 mutations have an 80-100 times high risk for the development of b
✦ LIBER ✦
RAD50gene mutations are not likely a risk factor for breast cancer in Poland
✍ Scribed by Maria Mosor; Iwona Ziółkowska-Suchanek; Krzysztof Rożnowski; Marta Baranowska; Danuta Januszkiewicz-Lewandowska; Jerzy Nowak
- Book ID
- 106378832
- Publisher
- Springer US
- Year
- 2010
- Tongue
- English
- Weight
- 164 KB
- Volume
- 123
- Category
- Article
- ISSN
- 0167-6806
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## Abstract Genetic risk factors for male breast cancer (MBC) are poorly understood. High penetrance genes such as BRCA1 or BRCA2 account for only a small proportion of the disease. A 1100delC mutation in CHEK2 (previously known as CHK2), a cell‐cycle checkpoint kinase, has been implicated in predi