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Are hemochromatosis gene (HFE) mutations a risk factor for colon cancer?

✍ Scribed by Shaheen, Nicholas J.; Sandler, Robert S.; Silverman, Lawrence M.; Keku, Temitope O.; Lawrence, Laura B.; Martin, Christopher F.; Maynard, Robert; Rohlfs, Elizabeth M.

Book ID
121977607
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
171 KB
Volume
118
Category
Article
ISSN
0016-5085

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## Abstract Cancer cells require large amounts of micronutrients, particularly iron, for their rapid growth and frequent divisions. Cellular iron uptake is regulated by the transferrin receptor and the hemochromatosis protein (HFE) system. Two frequent mutations in the __HFE__ gene, H63D and C282Y,