Racemic-2,3-dimercaptosuccinic Acid for Inorganic Mercury Mobilization in Rats

✍ Scribed by K. Kostial; N. Restek-Samaržija; M. Blanuša; M. Piasek; Lj. Prester; M. M. Jones; P. K. Singh

• Publisher: John Wiley and Sons
• Year: 1997
• Tongue: English
• Weight: 116 KB
• Volume: 17
• Category: Article
• ISSN: 0260-437X
• DOI: 10.1002/(sici)1099-1263(199701)17:1<71::aid-jat395>3.0.co;2-u

✦ Synopsis

The efficiency of racemic-2,3-dimercaptosuccinic acid (rac-DMSA) compared with meso-2,3-dimercaptosuccinic acid (meso-DMSA) in mobilizing inorganic mercury was evaluated in female rats. Chelators were administered orally at a dose of 0.5, 1.0 or 2.0 mmol kg ؊1 on four consecutive days, 5 days after a single intraperitoneal 203 Hg injection (with 0.5 mg HgCl 2 kg ؊1 ). Both chelators reduced 203 Hg retention in whole body and kidney and at higher doses also in the liver. Racemic-DMSA was more efficient at lower dose levels and equal to meso-DMSA at the highest dose level. Kidney retention decreased after rac-DMSA to 27, 10 and 10% of controls and after meso-DMSA to 68, 39 and 10% of control values at the 0.5, 1.0 and 2.0 mmol kg ؊1 dose level, respectively. Since meso-DMSA is already approved for human use, its stereoisomeric form, rac-DMSA, deserves further attention for treatment of mercury poisoning.