Mobilization of lead in mice by administration of monoalkyl esters of meso-2,3-dimercaptosuccinic acid
โ Scribed by Ernest M. Walker Jr.; Angie Stone; Lynda Beth Milligan; Glen R. Gale; Loretta M. Atkins; Alayne B. Smith; Mark M. Jones; Pramod K. Singh; Mark A. Basinger
- Publisher
- Elsevier Science
- Year
- 1992
- Tongue
- English
- Weight
- 548 KB
- Volume
- 76
- Category
- Article
- ISSN
- 0300-483X
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The effect of nine monoalkyl esters of meso-2,3-dimercaptosuccinic acid (DMSA) on '03Hg retention after a single i.p. dose was evaluated in 6-7 week-old female albino rats. The monoesters were the monomethyl (MMDMS), monoethyl (MEDMS), mono-n-propyl (Mn-PDMS), monoisopropyl (Mi-PDMS), mono-n-butyl (
## Abstract The effects of __meso__โ2,3โdimercaptosuccinic acid (DMSA) and 2,3โdimercaptopropane sulphonate (DMPS) on body beryllium burden, hepatic lipid peroxidation, glutathione, alkaline and acid phosphatase and some biochemical variables of porphyrin metabolism were studied in berylliumโpoison
Monoisoamyl (Mi-ADMS) and mono-n-hexyl (Mn-HDMS) monoesters of meso-2,3-dimercaptosuccinic acid (DMSA) were given orally or parenterally for the mobilization of inorganic mercury in suckling and older rats. Chelators were administered at a dose of 2 x 0.5 mmol kg-1 on two consecutive days 2 weeks af