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Therapeutic potential of meso 2,3-dimercaptosuccinic acid or 2,3-dimercaptopropane 1-sulfonate in chronic arsenic intoxication in rats

✍ Scribed by S. J. S. Flora; S. N. Dube; Usha Arora; G. M. Kannan; M. K. Shukla; P. R. Malhotra

Publisher
Springer Netherlands
Year
1995
Tongue
English
Weight
463 KB
Volume
8
Category
Article
ISSN
1572-8773

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✦ Synopsis

The therapeutic efficacy of two thiol chelators, meso 2,3-dimercaptosuccinic acid (DMSA) or 2,3-dimercaptopropane sulfonate (DMPS) in treating chronic arsenic intoxication was investigated in male rats. Both the chelators were effective in promoting urinary arsenic excretion and restoring arsenic induced inhibition of blood 6-aminolevulinic acid dehydratase activity and hepatic glutathione level. Elevation of urinary b-aminolevulinic acid excretion and arsenic concentration in blood, liver and kidneys were reduced significantly by both the chelators. Histopathological lesions induced by arsenic were also effectively reduced by the above chelators. DMSA being more effective than DMPS. The results suggest DMSA and DMPS to be effective antidotes for treating chronic arsenic toxicity in experimental animals.

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Beryllium-induced biochemical alteration
Beryllium-induced biochemical alterations and their prevention following Co-administration of Meso-2,3-dimercaptosuccinic acid or 2,3-dimercaptopropane sulphonate in rats
✍ Seema Mathur; R. Mathur; S. J. S. Flora; G. M. Kannan; S. Das Gupta 📂 Article 📅 1994 🏛 John Wiley and Sons 🌐 English ⚖ 631 KB

## Abstract The effects of __meso__‐2,3‐dimercaptosuccinic acid (DMSA) and 2,3‐dimercaptopropane sulphonate (DMPS) on body beryllium burden, hepatic lipid peroxidation, glutathione, alkaline and acid phosphatase and some biochemical variables of porphyrin metabolism were studied in beryllium‐poison