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R043: HOP, A Novel Tumor Suppressor Gene in Head and Neck SCCA

โœ Scribed by Frank G. Ondrey; Tyler G. Kimbrough; Beverly R. Wuertz; Gema Souto Adeva


Book ID
116813051
Publisher
SAGE Publications
Year
2007
Tongue
English
Weight
34 KB
Volume
137
Category
Article
ISSN
0194-5998

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The candidate tumor-suppressor gene ING1 encodes p33 ING1 , a nuclear protein which physically interacts with TP53. It has been shown that p33 ING1 acts in the same biochemical pathway as TP53, leading to cell growth inhibition. Interestingly, a rearrangement of the ING1 gene was found in a neurobla