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Evidence of two tumor suppressor genes on chromosome 8p in head and neck squamous cell carcinoma

✍ Scribed by John B. Sunwoo; Steven B. Scholnick; Bruce H. Haughey; Samir K. El-Mofty


Book ID
117400855
Publisher
SAGE Publications
Year
1995
Tongue
English
Weight
111 KB
Volume
113
Category
Article
ISSN
0194-5998

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## Abstract The aim of our study was to analyze the alterations of some candidate tumor suppressor genes (TSGs) viz. __LIMD1__, __LTF__, __CDC25A__, __SCOTIN__, __RASSF1A__ and __CACNA2D2__ located in the chromosomal region 3p21.31 associated with the development of early dysplastic lesions of head

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Loss of heterozygosity studies of a variety of human tumors suggest that there are several tumor suppressor genes on chromosome arm 8p. To localize these genes more precisely. we utilized polymerase chain reaction amplification of microsatellie repeat polymorphism and examined the allelic IOU patter