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Quinolinic acid reduces the antioxidant defenses in cerebral cortex of young rats

✍ Scribed by Guilhian Leipnitz; Cristiana Schumacher; Karina Scussiato; Karina B. Dalcin; Clóvis M.D. Wannmacher; Angela T.D. Wyse; Carlos S. Dutra-Filho; Moacir Wajner; Alexandra Latini


Book ID
116551377
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
157 KB
Volume
23
Category
Article
ISSN
0736-5748

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✍ Guilhian Leipnitz; Bianca Seminotti; Josué Haubrich; Manuela B. Dalcin; Karina B 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 342 KB 👁 1 views

## Abstract In the present work we investigated the in vitro effect of 3‐hydroxy‐3‐methylglutarate (HMG) that accumulates in 3‐hydroxy‐3‐methylglutaryl‐CoA lyase deficiency (HMGLD) on important parameters of oxidative stress in rat cerebral cortex. It was observed that HMG induced lipid peroxidatio