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Neurochemical evidence that phytanic acid induces oxidative damage and reduces the antioxidant defenses in cerebellum and cerebral cortex of rats

✍ Scribed by Guilhian Leipnitz; Alexandre U. Amaral; Ângela Zanatta; Bianca Seminotti; Carolina G. Fernandes; Lisiane A. Knebel; Carmen R. Vargas; Moacir Wajner


Book ID
116719828
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
468 KB
Volume
87
Category
Article
ISSN
0024-3205

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## Abstract In the present work we investigated the in vitro effect of 3‐hydroxy‐3‐methylglutarate (HMG) that accumulates in 3‐hydroxy‐3‐methylglutaryl‐CoA lyase deficiency (HMGLD) on important parameters of oxidative stress in rat cerebral cortex. It was observed that HMG induced lipid peroxidatio