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α-Keto Acids Accumulating in Maple Syrup Urine Disease Stimulate Lipid Peroxidation and Reduce Antioxidant Defences in Cerebral Cortex From Young Rats

✍ Scribed by Raquel Bridi; César A. Braun; Giovanni K. Zorzi; Clóvis M. D. Wannmacher; Moacir Wajner; Eduardo G. Lissi; Carlos Severo Dutra-Filho

Book ID: 106459859
Publisher: Springer
Year: 2005
Tongue: English
Weight: 203 KB
Volume: 20
Category: Article
ISSN: 0885-7490
DOI: 10.1007/s11011-005-4152-8

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## Abstract Severe neurological symptoms, cerebral edema, and atrophy are common features of the inherited metabolic disorder maple syrup urine disease (MSUD). However, the pathomechanisms involved in the neuropathology of this disease are not well established. In this study, we investigated the ef