Quinidine, “pure quinidine,” and hydroquinidine: I. Toxicity
✍ Scribed by S.A. Weisman
- Book ID
- 119387670
- Publisher
- Elsevier Science
- Year
- 1942
- Tongue
- English
- Weight
- 244 KB
- Volume
- 24
- Category
- Article
- ISSN
- 1097-6744
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📜 SIMILAR VOLUMES
NMR spectra of quinidine (I), hydroquinidine (II), and their respective acetyl derivatives (III and IV) were compared. The chemical shifts of some protons in I differed from those of their counterparts in II. These values were concentration dependent in I and II; they were similar in III and IV but
A case of agranulocytosis in an 86-year-old man after 8 weeks treatment with quinidine sulfate is described. Acute phase serum from the patient demonstrated antineutrophil activity by the microgranulocytotoxicity assay. Review of the literature reveals that more than one mechanism could cause this i