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NMR spectroscopic determination of preferred conformations of quinidine and hydroquinidine

✍ Scribed by Yehuda Yanuka; Shimona Yosselson Superstine; Edward Superstine

Publisher
John Wiley and Sons
Year
1979
Tongue
English
Weight
486 KB
Volume
68
Category
Article
ISSN
0022-3549

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✦ Synopsis

NMR spectra of quinidine (I), hydroquinidine (II), and their respective acetyl derivatives (III and IV) were compared. The chemical shifts of some protons in I differed from those of their counterparts in II. These values were concentration dependent in I and II; they were similar in III and IV but not concentration dependent. The implications of these findings and the correlation of the NMR data with the preferred conformations are discussed.

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