Quinidine-digoxin interaction: Effect of quinidine on86Rb-uptake of human erythrocytes
β Scribed by Doering, W. ;Belz, G. G.
- Publisher
- Springer-Verlag
- Year
- 1981
- Tongue
- English
- Weight
- 263 KB
- Volume
- 59
- Category
- Article
- ISSN
- 1432-1440
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π SIMILAR VOLUMES
Ionic strength and ionic specificity were found to have a significant influence on the rectal absorption of gentamicin. Sodium was more effective than potassium in promoting rectal absorption, but the enhancing effect of sodium salicylate could not be totally explained on the basis of ionic strength
Following i.v. injection of digoxin (1Opg kg-') the ratio between digoxin concentrations in the lumen ofjejunal loops perfused in situ and in plasma (L/P) of guinea pigs increased linearily with time. After 3 h, L/P was 8.7, indicating net secretion of digoxin against a concentration gradient. In qu