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Effect of quinidine on the intestinal secretion of digoxin in guinea pigs

✍ Scribed by S. G. Schäfer; B. Fichtl; W. Doering

Publisher
John Wiley and Sons
Year
1984
Tongue
English
Weight
250 KB
Volume
5
Category
Article
ISSN
0142-2782

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✦ Synopsis

Following i.v. injection of digoxin (1Opg kg-') the ratio between digoxin concentrations in the lumen ofjejunal loops perfused in situ and in plasma (L/P) of guinea pigs increased linearily with time. After 3 h, L/P was 8.7, indicating net secretion of digoxin against a concentration gradient. In quinidine treated animals (100mg kg-' P.o., 2 h before experiment) both the L/P ratio (5.7; p <0.01) and the digoxin content of jejunal tissue ( -32 per cent; p <0.01) were markedly reduced. It is suggested that quinidine reduces the extrarenal clearance of digoxin at least in part by inhibiting the intestinal secretion of this gl ycoside.

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