Electrophysiological effects of Ageratum conyzoides L. on the guinea-pig heart

✍ Scribed by E. A. Conde Garcia; M. Paula Carvalho

• Publisher: John Wiley and Sons
• Year: 1999
• Tongue: English
• Weight: 75 KB
• Volume: 13
• Category: Article
• ISSN: 0951-418X
• DOI: 10.1002/(sici)1099-1573(199903)13:2<172::aid-ptr394>3.0.co;2-z

✦ Synopsis

An extract obtained from the leaves of Ageratum conyzoides L. changed the electrocardiogram, atrial impulse velocity, and coronary vessels resistance on isolated guinea-pig heart. Electrocardiographic alterations were: (a) PR interval increased from 80 AE 1.4 ms to 105 AE 14 ms (p 0.01); (b) QT interval decreased from 170 AE 2 ms to 154 AE 7 ms (p 0.01); (c) heart rate decreased from 170 AE 17 bpm to 152 AE 21 bpm (p 0.01);(d) atrial impulse velocity decreased from 51 AE 2 cm/s to 45 AE 3 cm/s (p 0.01);(e) the time spent for the impulse to be conducted from the atrium to the His bundle increased from 73 AE 13 ms to 100 AE 24 ms (p `0.01). These effects disappeared after a washout.