✦ LIBER ✦

Effect of quinidine on digoxin distribution and elimination in guinea pigs

✍ Scribed by Jun Sato; Yasufumi Sawada; Tatsuji Iga; Manabu Hanano

Publisher: John Wiley and Sons
Year: 1983
Tongue: English
Weight: 637 KB
Volume: 72
Category: Article
ISSN: 0022-3549
DOI: 10.1002/jps.2600721007

No coin nor oath required. For personal study only.

✦ Synopsis

Ionic strength and ionic specificity were found to have a significant influence on the rectal absorption of gentamicin. Sodium was more effective than potassium in promoting rectal absorption, but the enhancing effect of sodium salicylate could not be totally explained on the basis of ionic strength. These data, while helping to elucidate some parameters that affect rectal drug absorption, may offer potential insights into new formulation designs for systemic delivery of water-soluble drugs from the rectal compartment.

REFERENCES

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