Quantitative Similarity-Based Association Tests Using Population Samples
โ Scribed by Shuanglin Zhang; Hongyu Zhao
- Book ID
- 117853680
- Publisher
- American Society of Human Genetics
- Year
- 2001
- Tongue
- English
- Weight
- 164 KB
- Volume
- 69
- Category
- Article
- ISSN
- 0002-9297
- DOI
- 10.1086/323037
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
## Abstract In a genetic association study, it is often desirable to perform an overall test of whether any or all singleโnucleotide polymorphisms (SNPs) in a gene are associated with a phenotype. Several such tests exist, but most of them are powerful only under very specific assumptions about the
Asthma is a common, complex human disease. Elevated serum immunoglobulin E (IgE) levels, elevated blood eosinophil counts, and increased airway responsiveness are physiological traits that are characteristic of asthma. Few studies have investigated major gene effects for these traits in a population
## Abstract Association tests based on multiโmarker haplotypes may be more powerful than those based on single markers. The existing association tests based on multiโmarker haplotypes include Pearson's ฯ^2^ test which tests for the difference of haplotype distributions in cases and controls, and ha