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Quantitative determination of binding of anthracycline antibiotics with DNA

โœ Scribed by T. A. Bogush; E. P. Baranov; S. V. Egudina; N. I. Tankovich


Book ID
104940867
Publisher
Springer US
Year
1992
Tongue
English
Weight
236 KB
Volume
113
Category
Article
ISSN
0007-4888

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The binding of the anthracyclines beta-rhodomycin-I and beta-rhodomycin-II to calf thymus DNA was investigated by both equilibrium and kinetic methods taking into account ligand dimerization (ionic strength I = 0.2 M, pH 6.0). The analysis was based upon a cooperative single-step binding mechanism w