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Dissection of the free energy of anthracycline antibiotic binding to DNA: electrostatic contributions

✍ Scribed by Chaires, J. B.; Priebe, W.; Graves, D. E.; Burke, T. G.


Book ID
120182604
Publisher
American Chemical Society
Year
1993
Tongue
English
Weight
616 KB
Volume
115
Category
Article
ISSN
0002-7863

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Electrostatic contribution to the energy
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## Abstract The method of solution of the nonlinear Poisson–Boltzmann equation was used to calculate electrostatic energy of binding of various aromatic ligands with DNA oligomers of different length. Analysis of the electrostatic contribution was made in terms of a two‐step DNA binding process: fo