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Electrostatic and non-electrostatic contributions to the binding free energies of anthracycline antibiotics to DNA

✍ Scribed by Maciej Baginski; Federico Fogolari; James M Briggs

Book ID
115628238
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
471 KB
Volume
274
Category
Article
ISSN
0022-2836

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## Abstract The method of solution of the nonlinear Poisson–Boltzmann equation was used to calculate electrostatic energy of binding of various aromatic ligands with DNA oligomers of different length. Analysis of the electrostatic contribution was made in terms of a two‐step DNA binding process: fo