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Interaction of new anthracycline antibiotics with DNA. Effects on nucleic acid synthesis and binding to DNA

✍ Scribed by Tadazumi Komiyama; Toshikazu Oki; Taiji Inui


Book ID
119119198
Publisher
Elsevier Science
Year
1983
Tongue
English
Weight
518 KB
Volume
740
Category
Article
ISSN
0167-4781

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Interaction of anthracycline antibiotics
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The binding of the anthracyclines beta-rhodomycin-I and beta-rhodomycin-II to calf thymus DNA was investigated by both equilibrium and kinetic methods taking into account ligand dimerization (ionic strength I = 0.2 M, pH 6.0). The analysis was based upon a cooperative single-step binding mechanism w