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Quantitative assessment of the effect of 0.05% chlorhexidine on rat articular cartilage metabolism in vitro and In vivo

✍ Scribed by A. D. Reading; P. Rooney; G. J. S. Taylor

Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
578 KB
Volume
18
Category
Article
ISSN
0736-0266

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✦ Synopsis

Abstract

Wound infection remains a problem. Syringe and needle jet lavage of chlorhexidine gluconate 0.05% removed or killed 99.8% of contaminating bacteria within 1 minute in a wound model. In clinical use, however, possibletoxicity to articular cartilage is a concern. In an established intact rat patella model in vitro, 1 minute of exposure to chlorhexidine 0.05% and chlorhexidine jet lavage did not significantly alter cartilage metabolism. A 1‐hour exposure decreased metabolic activity. In vivo, a 30‐minute exposure with or without rinsing produced no impairment of metabolic activity 6 weeks later, suggesting that cartilage has the potential for biological recovery. However, injecting and leaving chlorhexidine 0.05% in the joints was detrimental to the metabolic activity of the articular cartilage as assessed 6 weeks later. Thus, chlorhexidine gluconate 0.05% could be used on normal articular cartilage. Any potential damage from prolonged exposure can be avoided by rinsing after 1 minute.

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