✦ LIBER ✦

In vitro and in vivo effects of metal chelators on cartilage metabolism

✍ Scribed by Dr. Michael G. Ehrlich; Ray Stefanich; Kenneth K. Ishizue; Ann L. Armstrong; Henry J. Mankin

Publisher: Elsevier Science
Year: 1990
Tongue: English
Weight: 545 KB
Volume: 8
Category: Article
ISSN: 0736-0266
DOI: 10.1002/jor.1100080109

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The effect of metallic chelating agents (EDTA, EGTA) on cartilage metabolism was studied both in vitro, on calf cartilage, and in vivo, in rabbits. The question asked was whether it was possible to affect neutral protease activity, and not also inhibit beneficial synthetic systems. In vitro, EDTA suppressed anabolic processes, while EGTA had no effect. However, EDTA in vivo did not suppress glycosaminoglycan or RNA production, but paradoxically stimulated them. At the same time, EDTA inhibited neutral protease activity in normal animals.

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