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Quantitative assay of diclofenac in biological material by gas—liquid chromatography

✍ Scribed by U.P. Geiger; P.H. Degen; A. Sioufi

Publisher
Elsevier Science
Year
1975
Tongue
English
Weight
405 KB
Volume
111
Category
Article
ISSN
1873-3778

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✦ Synopsis

Diclofenac and an internal standard are isolated from biological samples by acid-specific extraction and converted into the corresponding indolones with 0.5% sulphuric acid in 2,2,2-trifluorethanol. The neutral derivatives are isolated by solvent extraction and subjected to gas-liquid chromatography. The use of an electron capture detector permits the assay of diclofenac at levels down to 2 ng per sample.

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