𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Quantitative analysis of drug handling by the kidney using a physiological model of renal drug clearance

✍ Scribed by I. Janků; K. Zvara


Publisher
Springer
Year
1993
Tongue
English
Weight
508 KB
Volume
44
Category
Article
ISSN
0031-6970

No coin nor oath required. For personal study only.


📜 SIMILAR VOLUMES


A physiologically based kidney model for
✍ Sandra P. A. Boom; Ineke Meyer; Alfons C. Wouterse; Frans G. M. Russel 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 186 KB 👁 2 views

Ranitidine renal clearance was investigated in the beagle dog with or without concomitant infusion of cimetidine or probenecid. Ranitidine was excreted mainly by renal tubular secretion. Plasma clearance was reduced by probenecid from 198 9 47 to 119 9 41 mL min -1 (mean9 S.D.); renal clearance was

A priori prediction of tissue:plasma par
✍ Patrick Poulin; Frank-Peter Theil 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 374 KB 👁 3 views

The tissue:plasma (P t:p ) partition coefficients (PCs) are important drugspecific input parameters in physiologically based pharmacokinetic (PBPK) models used to estimate the disposition of drugs in biota. Until now the use of PBPK models in early stages of the drug discovery process was not possib

Utility of a physiologically–based pharm
✍ Joseph A. Grillo; Ping Zhao; Julie Bullock; Brian P. Booth; Min Lu; Kathy Robie- 📂 Article 📅 2012 🏛 John Wiley and Sons 🌐 English ⚖ 535 KB

Background: Rivaroxaban is an oral Factor Xa inhibitor. The primary objective of this communication was to quantitatively predict changes in rivaroxaban exposure when individuals with varying degrees of renal impairment are co-administered with another drug that is both a P-gp and a moderate CYP3A4