The problem of optimal dosage is studied for the administration of ddCyd using erythrocytes as carriers and bioreactors. The volume of erythrocytes and the initial amount of drug to be loaded have to be determined in such a way that the duration of the therapeutic effect is maximized without exceedi
β¦ LIBER β¦
A mathematical model for drug administration by using the phagocytosis of red blood cells
β Scribed by Edoardo Beretta; Fortunata Solimano; Yasuhiro Takeuchi
- Publisher
- Springer
- Year
- 1996
- Tongue
- English
- Weight
- 326 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0303-6812
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## Abstract The demand for blood components is constantly increasing, while the exclusion criteria for donors are strengthened in order to reach maximal safety for donors and patients. To counterbalance reduced availability of volunteers, multicomponent collections (MCC) is an attractive approach t