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Quantitative analysis of allosteric drug-protein binding by biointeraction chromatography

✍ Scribed by Chen, Jianzhong; Hage, David S

Book ID
109908304
Publisher
Nature Publishing Group
Year
2004
Tongue
English
Weight
162 KB
Volume
22
Category
Article
ISSN
1087-0156

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## Abstract Interactions of the drug carbamazepine with the serum protein Ξ±~1~‐acid glycoprotein (AGP) were examined by high‐performance affinity chromatography. Frontal analysis studies with an immobilized AGP column and control column indicated carbamazepine had both low‐affinity interactions wit