A simple method is described for demonstrating adaptation to alkylation damage in Aspergillus nidulans. One wild type, two MNNG-sensitive, and one MNNG-resistant strain all showed improvement in colony growth when challenged with MNNG following appropriate inducing pretreatments. Other alkylating ag
Quantitation of the adaptive response to alkylating agents
โ Scribed by ROBINS, PETER; CAIRNS, JOHN
- Book ID
- 109714464
- Publisher
- Nature Publishing Group
- Year
- 1979
- Tongue
- English
- Weight
- 359 KB
- Volume
- 280
- Category
- Article
- ISSN
- 0028-0836
- DOI
- 10.1038/280074a0
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
Six mutant strains of Bacillus subtilis hypersensitive to N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) were shown to be deficient in the adaptive response to MNNG and termed ada mutants (Morohoshi and Munakata 1985). All the mutations mapped between the attSPO2 and lin loci on the chromosome. The mut
The ada+ gene of E. coli is a regulatory gene of the adaptive response to simple alkylating agents. ada mutants are sensitive to both the mutagenicity and toxicity of alkylating agents, and are unable to induce O6-methylguanine DNA methyltransferase and 3-methyladenine DNA glycosylase II. The ada+ g