✦ LIBER ✦

Quantitation of lipid in biological tissue by chemical shift magnetic resonance imaging

✍ Scribed by Wai-Fan Wong; S. Robert Northrup; Richard C. Herrick; Alan P. Glornbicki; R. Patrick Wood; Joel D. Morrisett

Publisher: John Wiley and Sons
Year: 1994
Tongue: English
Weight: 768 KB
Volume: 32
Category: Article
ISSN: 0740-3194
DOI: 10.1002/mrm.1910320403

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

A method combining several previously used approaches is described for the rapid, accurate quantitation of the fat content of biological tissue based on chemical shift images (CSI) corrected for magnetic field inhomogeneity, and compensated for T~1~, and T~2~, effects. The gravimetrically determined lipid content of fatty tissues (pork fat, rabbit and human liver) that had been differentially depleted of lipid by chloroform extraction correlated well (r = 0.99) with the lipid image intensities of the respective tissues. This multi‐point CSI method was used to quantitate lipid in fresh fatty human liver tissue (wet and dry) containing varying amounts of lipid. Plots of integrated lipid intensity versus tissue lipid content gave straight parallel lines for hydrated (r = 0.94) and dehydrated (r = 0.98) tissues, permitting determination of a proportionality constant for measuring absolute amounts of lipid present in a specific biological tissue. These results suggest the feasibility of using the method in vivo for absolute quantitation of lipid in tissues of agricultural (e.g. pork, beef) and medical (e.g. human liver) interest.

📜 SIMILAR VOLUMES

Chemical shift imaging in nuclear magnet

Chemical shift imaging in nuclear magnetic resonance: A comparison of methods

✍ Rumpel, Helmut ;Pope, James M. 📂 Article 📅 1993 🏛 John Wiley and Sons 🌐 English ⚖ 844 KB

Chemical shift imaging techniques are magnetic resonance imaging methods that separately map the spatial distribution of individual peaks or components in a complex NMR spectrum. A range of chemical shift imaging techniques based around the commonly employed spin-echo Fourier imaging sequences is cl

Chemical-Shift Magnetic Resonance Imagin

Chemical-Shift Magnetic Resonance Imaging of Two-Line Spectra by Gradient Reversal

✍ Leon Axel; Gary Glover; Norbert Pelc 📂 Article 📅 1985 🏛 John Wiley and Sons 🌐 English ⚖ 448 KB

A method of chemical-shift imaging is described using the invariance of chemical shifts to changes in magnetic field gradients used for frequency encoding of position in imaging. This enables separation of the effects on the observed signal of chemical shift from the effects of different positions a

Tissue characterization of symptomatic a

Tissue characterization of symptomatic and asymptomatic disc herniations by quantitative magnetic resonance imaging

✍ Norbert Boos; Daniel Dreier; Esther Hilfiker; Volker Schade; Roland Kreis; Josef 📂 Article 📅 1997 🏛 Elsevier Science 🌐 English ⚖ 928 KB

## Abstract The purpose of this investigation was to determine differences in tissue composition of symptomatic and asymptomatic disc herniations as reflected in T~1~ and T~2~ relaxation times (quantitative magnetic resonance investigation of the lumber spine. The longitudinal and transverse magnet

Atraumatic quantitation of cerebral perf

Atraumatic quantitation of cerebral perfusion in cats by 19f magnetic resonance imaging

✍ Craig A. Branch; James R. Ewing; J. A. Helpern; R. J. Ordidge; Shazad Butt; K. M 📂 Article 📅 1992 🏛 John Wiley and Sons 🌐 English ⚖ 1004 KB

## Abstract We have noninvasively produced low‐resolution, quantitative nuclear magnetic resonance images of cerebral blood flow in 2‐ml voxels in eight cats. Typical signal‐to‐noise of 4 to 1 was obtained in cerebral voxels in 16.5‐s epochs. Mean flow during normocapnia (p~a~CO~2~ = 39 ± 4 mm Hg)

Expansion of the spectral bandwidth by s

Expansion of the spectral bandwidth by spatial and chemical shift selective saturation in high-speed magnetic resonance spectroscopic imaging

✍ Satoshi Hirata; Yoshitaka Bito; Etsuji Yamamoto 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 724 KB

## Abstract A new spectral bandwidth expansion technique for highspeed magnetic resonance spectroscopic imaging (MRSI) based on an echo‐planar technique is presented. This expansion can be achieved by spatial and chemical shift selective saturation without increasing the total measurement time. In

Observation of cardiac lipids in humans

Observation of cardiac lipids in humans by localized 1H magnetic resonance spectroscopic imaging

✍ Jan A. den Hollander; William T. Evanochko; Gerald M. Pohost 📂 Article 📅 1994 🏛 John Wiley and Sons 🌐 English ⚖ 609 KB

## Abstract Different approaches are being explored for the noninvasive observation of myocardial lipids in the human heart by __in vivo__ ^1^H NMR spectroscopy. One approach is to measure cardiac lipids using a combination of volume selection and 2D gradient phase encoding. From these data sets li